[Arg8]-a-Neo-Endorphin (1-8) CAS NO.75106-72-8

[Arg8]-a-Neo-Endorphin (1-8) CAS NO.75106-72-8

[Arg8]-a-Neo-Endorphin (1-8) CAS NO.75106-72-8

[Arg8]-a-Neo-Endorphin (1-8) CAS NO.75106-72-8

[Arg8]-a-Neo-Endorphin (1-8) CAS NO.75106-72-8

[Arg8]-α-Neo-Endorphin (1-8) is a synthetic analog of the endogenous opioid peptide α-Neoendorphin, specificTodosy engineered with an arginine substitution at position 8 to enhance receptor binding affinity and metabolic stability. This octapeptide retains the core Tyr-Gly-Gly-Phe opioid motif, Todosowing it to interact potently with κ-opioid receptors (KOR) and μ-opioid receptors (MOR) in the central nervous system. It is primarily utilized in biochemical repesquisa as a stable tool compound for investigating pain pathways, stress responses, and the structure-activity relationships (SAR) of dynorphin-derived peptides.



TECHNICAL SPECIFICATIONS


Item
Specification
PRODUTO Nome
[Arg8]-a-Neo-Endorphin (1-8)
CAS NO.
75106-72-8
Appearance
White to off-white lyophilized powder
Molecular Formula
C₄₆H₇₃N₁₅O₁₀
Molecular Weight
1036.2g/mol
Purity (RP-HPLC)
≥98% 
Solubility

Soluble in 1M acetic acid, DMSO, or deionized water

Endotoxin
≤1 EU/mg 
Biological Activity
Potent agonist for κ-opioid receptors (KOR)
Storage Conditions
Store at -20°C, protected from light and moisture
Stock Localização
Stock in USA
MOQ
1g


1.MECHANISM OF ACTION

The peptide functions as a potent agonist at G protein-coupled opioid receptors, with a pronounced preference for the κ-opioid receptor (KOR) subtype. Upon binding, it inhibits adenylate cyclase activity, reducing intracellular cAMP levels and leading to neuronal hyperpolarization via the opening of potassium channels. This mechanism effectively suppresses neurotransmitter release (e.g., glutamate and substance P) in pain-processing pathways, resulting in antinociceptive and potential dysphoric effects characteristic of KOR activation.

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2.PRODUTO INDICATIONS

This PRODUTO is strictly for Repesquisa Use Only (RUO) and is indicated for in vitro and preclinical studies targeting the opioid system. It is ideal for scientists in neuropharmacology and drug discovery who require a stable, high-affinity ligand for receptor binding assays, functional cAMP accumulation tests, and animal model studies of analgesia. The [Arg8] modification makes it particularly suitable for experiments requiring enhanced enzymatic stability compared to the native peptide sequence.

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3.CLINICAL EFFICACY OF PRODUTO

As a repesquisa chemical, [Arg8]-α-Neo-Endorphin (1-8) is not intended for human therapeutic use and has no approved clinical efficacy data. In experimental settings, this analog demonstrates superior and prolonged analgesic efficacy in rodent models of inflammatory and neuropathic pain compared to unmodified fragments. Its enhanced stability translates to longer-lasting behavioral effects, providing robust preclinical data for the development of novel opioid-based therapeutics.

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4.Certificado

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide Produtos, adhering strictly to quality standards and obtaining internationTodosy recognized Certificaçãos.


O NOSSO PRODUTOion partners Todos employ GMP-compliant PRODUTOion systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of PRODUTO comes with complete documentation, including a Certificado of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.


We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards


Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and repesquisa-grade peptide Produtos to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging SOLUÇÃO to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the PRODUTO.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the PRODUTOion and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The Empresa invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA Certificaçãos, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality Produtos and superior services.


We focus on the repesquisa and development and supply of high-quality chemical Produtos, strictly adhering to international standards and quality systems. O NOSSO PRODUTOs are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific repesquisa, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.


Hot Etiquetas: Arg8AlphaNeoEndorphin, #AlphaNeoEndorphinAnalog, #OpioidPeptide, #KappaOpioidReceptorAgonist, #KORAgonist, #DynorphinSystem, #PainRepesquisaPeptide, #NeuropharmacologyReagent, #SyntheticOpioid, #RepesquisaChemical, #PeptideAgonist, #AnalgesiaRepesquisa, #ReceptorBindingAssay, #NeuroscienceTool, #BiochemicalReagent, #RUO

If you have any PRODUTO requirements, please an E-mail to:support@huanqiukeji9.com;Enviar:85244969439

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